A subset of projects being designed, that are in progress and that have graduated.
The Nursing Care for Substance Use Disorder study explores whether in-person, patient first language training sessions at Penn nursing units and/or weekly educational text messaging affect nurses' attitudes towards patients with substance use disorder. Nurses complete a survey before and after receiving the 6-month intervention to measure changes in attitudes.
Ongoing Research & Analysis
By identifying an optimal set of intervention components to increase sleep duration, SLEEPY 2.0 seeks to improve sleep duration and positive health outcomes for children with equitable effectiveness across socio-demographic backgrounds in Philadelphia.
Ongoing Research & Analysis
This program supports Self-Management of Healthy Behaviors (SMART-HABITS) for Health tests the effectiveness of peer support and social norms for blood pressure monitoring in patients with chronic kidney disease (CKD), diabetes and hypertension. Through improving programs encouraging healthy behaviors among those living with CKD, SMART-HABITS aims to leverage study results to empower those living with CKD to optimally manage their disease.
Ongoing Research & Analysis
The ability to read, write, speak, think and respond critically can open the door to many possibilities across one's lifespan both in school and beyond, affecting how we interact with our communities, engage as citizens, consume health care, express ourselves and more. Often, children of low-income parents experience disparities in these critical areas of development. Parent-child shared reading can help ameliorate these disparities, yet low-income parents do not consistently engage in this activity. Behavioral economics approaches utilizing automated hovering (AH) have the potential to increase parent-child shared reading opportunities through text messages and financial inducements. Formerly referred to as Parent Child Reading Pilot. This study at CHOP aims to develop materials to frame an evidence base to promote parents reading with children. It tests lottery or regret language to explore if that promotes more reading with children.
Ongoing Research & Analysis
This study employs gamification to increase physical activity among Black and Hispanic breast and prostate cancer survivors across three sites: Penn Medicine, City of Hope and Montefiore.
Ongoing Research & Analysis
Mental health needs were disproportionately high among health care workers (HCWs) before the COVID-19 pandemic. However, the rapid spread of the disease forced providers to grapple with additional stressors, including longer shifts, shortages of personal protective equipment, increased mortality and morbidity, and isolation. Cobalt is a platform that was developed at Penn Medicine to assist with this challenge. The goal of this research program is to assess the impact of and perhaps increase engagement with the COBALT platform by sending surveys and nudges to create appointments. Based on responses to surveys, employees will get a different nudge depending on PHQ and GAD scores.
Ongoing Research & Analysis
The coronaVirus Impact on Birth Equity in the 4th trimester study explores the impact of COVID on birth outcomes. The program involves 10 days of twice daily postpartum BP monitoring followed by twice weekly BP monitoring and weekly weight collection. Participants at Penn and Mt. Sinai locations are enrolled into a high or low risk arm, each with its own unique BP algorithm and escalation pathway.
Ongoing Research & Analysis
This study is an open label trial of secukinumab to treat nail psoriasis utilizing W2H to administer patient and provider surveys, collect nail photos, and coordinate study data.
Ongoing Research & Analysis
This is the next generation of the Coloprep program. Based on learnings from prior iteration, the program has been updated to include bi-directional text messaging to help answer patient questions. The goal remains the same - improve colonoscopy show-rates and increase adherence to prep required. This update also includes integration to Epic which allows the program to automatically text patients based on their upcoming appointment. The integration also takes into account appointment reschedules and cancellations.
Ongoing Research & Analysis
Phillips CPAP devices are going through a recall. Sleep medicine needs help to engage patients via text so they send back the recalled device. Patients will get text(s) about how to register their device. Responses will be captured and clinical teams notified so appropriate action can be taken.
17800+ patients connected
Improved patient care
The BRIDGE program texts prediabetic women postpartum to educate them about their risk and motivate them to follow up with PCP to check their HbgA1C.
1. The number of women with repeat HbA1c value in 3 months postpartum
2. The number of referrals (or visits) to PCP in 6 months postpartum for women with persistent impaired glucose tolerance
RCT to motivate patients with anxiety to complete cognitive behavioral therapy (CBT) sessions twice weekly at home via a web app. The study arms use gamification, gamification with social support, and gamification with loss aversion to motivate CBT participation.
1. To develop and to test the feasibility of a mobile CBT tailored for youth with anxiety disorders.
2. Assess which incentives enhance engagement with mobile CBT for youth with anxiety disorders.
HSM WUSTL is a research program exploring the use of HSM at their location. Mothers with preeclampsia receive twice daily blood pressure check-ins through text message for 10 days after delivery. Blood pressure are categorized and escalations are sent to care teams for high/low readings. This program asks participants to complete an end of program survey to provide feedback on the program and the care they received while participating. See more here: https://www.pennmedicine.org/for-patients-and-visitors/find-a-program-or-service/obstetrics/heart-safe-motherhood .
1. Reduced HTN-related readmissions
2. Improved blood pressure management
The Nursing Care for Substance Use Disorder study explores whether in-person, patient first language training sessions at Penn nursing units and/or weekly educational text messaging affect nurses' attitudes towards patients with substance use disorder. Nurses complete a survey before and after receiving the 6-month intervention to measure changes in attitudes.
1. Develop an understanding of underlying substance use disorder (SUD)-related stigma among registered nurses at HUP
2. Evaluate the effects of sustained stigma-reduction activities on the individual and unit level
3. Evaluate a SUD stigma-assessment survey instrument tailored to hospital-based health care providers using psychometric analysis
Pregnancy of unknown location (PUL) is an automated texting program to manage follow up care for pregnancies not seen by ultrasound. Participants are reminded to return for blood draws every 2 days to measure their beta HCG levels and are also asked whether they have any worsening symptoms through text conversation. Abnormal HCG or symptoms result in patient follow up to determine whether the pregnancy is progressing as expected.
1. Increased adherence to follow up care including HCG lab draws
2. Increased quality of care for early pregnancy monitoring
Presby HTN is an automated BP monitoring program for hospital employees. Participants are asked to submit BPs twice weekly and are asked about BP medications weekly. Non-adherence tracking alerts clinicians if participants do not submit a BP for 3 or more check-ins.
1. Lowered SBP and DBP among participants
2. Increased medication adherence
SMART-HABITS is a crossover trial exploring the use of mHealth to improve self-management among pre-chronic kidney disease (CKD) patients. All participants receive FitBit step count monitoring with reminders. Half of the participants start with blood pressure monitoring using an Omron blood pressure cuff and crossover to texting in their blood pressures, and half do the opposite. Additionally, all participants receive educational messaging and information about social support resources.
1. Adoption: a) participant retention rate at 4, 8, and 12 weeks, b) Percentage of participants who used SMART-HABITS at any point during the 12 weeks.
2. Adherence: a) percentage of self-monitored BP transmissions performed out of the recommended and b) percentage of step count data transmissions out of the recommended.
3. Acceptability: a) improvement of the pre- and post-study scores on the attitudes toward mHealth questionnaire, b) satisfactory ratings on the ease of use survey during the study and at the end of the study and, c) interview feedback after the end of the pilot study.
This program screens patients through text to see if they are eligible and interested in scheduling their upcoming spondyloarthritis appointment via telemedicine.
1. Increase access to in-person appointments for patients with urgent needs (e.g., flares)
2. Provide quality follow up care for patients without urgent needs
Oncology patients spend a large proportion of their time attending in person clinical appointments. In TIME, a text-based intervention to minimize the time burden of routine clinical care, participants complete e-triage by text message. If cleared, they need not attend an office visit prior to their infusion appointment, reducing their travel time and number of in person appointments.
Potentally eliminating office visits for 47% of pts without toxicity
Increased patient satisfaction
Increased clinician satisfaction
Increased health system capacity
Strategies to maintain hospital capacity during the COVID-19 pandemic included reducing hospital length of stay (LOS) for infected patients. This program sought to evaluate the association between LOS and enrollment in the COVID Accelerated Care Pathway, which consisted of a hospital observation protocol and post-discharge automated text message–based monitoring. This program showed a reduction in hospital length of stay by more than 2 days.
Reduced length of stay by 2.2 days
Patient outcomes were unaffected
The intent of this study is to further explore the effect of collaboration and charity on increasing physical activity within families. The study specifically intends to test two interventions: 1) Gamification - using points to move participants up and down levels based on activity tracked through a Fitbit device, 2) Charity - using points to donate money to charity each week. Teams (cohorts) are created based on family members and the goal is to increase family physical activity.
Ongoing Research & Analysis
Directional trial to explore effectiveness of gamification to improve physical activity in Alzheimers patients. The project will be using points to move participants up and down levels (such as silver and bronze). Participants will be enrolled remotely or in-person.
Ongoing Research & Analysis
The Symptom Assessment Management program captures patient-reported outcomes (PROs) to understand how IV or Oral chemotherpay treatments impact the patient's quality of life (QOL). The program's extensive PRO algorithm was developed based on PRO-CTCAE grading and severity. Patients receive the PRO survey over text after their first treatment appointment multiple times over a 2-6 months to guage the impact on their QOL. This in turn can drive clinical decisions.
Ongoing Research & Analysis
Patients have delayed a number of wellness and care visits due to COVID. The intent of this program is to outreach to a broader population of Primary Care service line patients. This is in partnership with PCSL and Radiology. This is planned as a 2x2 factorial design RCT, as half the patients (about 17,000) will receive follow-up text messaging navigation. The goal is to show the health system that this might increase uptake so there can be sustainable resources to support bulk ordering, navigation, and text messaging.
Ongoing Research & Analysis
The intent of this project is to create a texting algorithm that will support post-operative calls with gyn-oncology patients. Enabling texting communication that would filter the acuity, and would allow over-burdened nursing staff to triage the patients in a more timely way, while still connecting with all of the patients post-operatively. If deployed, we see the scaling across the remainder of our surgical sub-specialties as a possibility.
Ongoing Research & Analysis
The intent of this clinical trial is to explore ways to improve the quality and number of serious illness conversations (SICs) with patients with a certain mortality risk or a documented Stage IV diagnosis. The nudges include pre-appointment reminders and a text based survey to both prime the conversation and also gather some of the patient's goals to better inform the upcoming appointment. Patient responses are collected and sent to the appropriate provider's in-basket.
Ongoing Research & Analysis
The intent of this study is to explore ways in which drivers could be incentivized to reduce mobile phone usage while driving. The goal being to reduce distracted driving related accidents. The study called for a partnership with Progressive Insurance and integration with its mobile application (managed by TrueMotion) to collect usage information. Multiple techniques such as possible insurance discounts, delivery of a phone mount, pre-commitment pledges, informational reminders, peer comparisons / leaderboards were used and are being evaluated. Initial results seem to indicate at least a couple of those techniques had success during the program and also during the follow-up period.
Ongoing Research & Analysis
The intent of this pilot is to use texting to outreach to patients discharged from the hospital on enteral nutrition (feeding tubes). Currently patients are discharged and there is no care home for them getting help or having questions asked around enteral nutrition leading to lots of follow-up calls and readmissions. The program will consist of twice weekly check-ins to see how the patients are doing. The goal of the pilot is to show patient engagement with text messaging. The longer term goal is to reduce readmission rates amongst this population.
Ongoing Research & Analysis
The intent is to pilot test texting ~150-200 Black patients discharged from the downtown EDs to ask about their experiences with race and equity via short surveys. This is a small, one time pilot to help inform future equity clinical work and research grants.
Ongoing Research & Analysis
Healthy Lungs is a PCORI-funded program that aims to improve lung health through a variety of techniques. Participants chosen as a good fit for this program receive free/ low cost tools to improve the health of their lungs and can even earn money. Eligible participants will have been referred for lung cancer screening from four health systems: Penn Medicine (including Lancaster General Health), Geisinger Health System, Kaiser Permanente of Southern California, and Henry Ford Health System. Question about this program should be directed to: [email protected].
Ongoing Research & Analysis
The intent of this program being run out of Michigan State University is to improve diabetic patients’ adherence to treatment and thus, increase prevention of cardiovascular disease. A comprehensive series of educational text messages are used to engage patients in their care.
Ongoing Research & Analysis
18 week, 2 arm RCT to test ways to promote intermittent fasting among patients who are overweight with high BP. Patients will receive a BP cuff and scale, without integration. Patients will receive daily texts asking if they've fasted for 16 hours, and weekly texts asking for weight and BP
Ongoing Research & Analysis
This program monitors pain management and opioid prescriptions for patients after surgery at Penn Medicine. This is a replacement for an existing program with an external vendor. The program implemented on Way to Health eliminates almost all of the manual work requires to run the program. It also adds bi-directional texting conversations with patients post-discharge to gather additional data from patients.
Ongoing Research & Analysis
This is a mega trial with planned enrollment of 150,000 patients across Penn Medicine and Geisinger Health system. The intent was to simultaneously test out 19 different nudges to figure out how to increase flu vaccination rates. The secondary intent was to use learnings from this to inform COVID vaccination efforts. The best performing nudge increases uptake by 11% over previous year baselines. The study was replicated with Walmart with 800,000+ participants.
Increased uptake by 11% over baseline
Text messaging effectiveness
In a concerted effort to address racial inequities. Penn Medicine partnered with Mercy Health, local pastors and the community in West and Southwest Philadelphia, to set up a community vaccination clinic. The goal was to vaccinate 500 individuals who met the 1A or 1B criteria set forth by the city. Way to Health provided the texting and IVR backends to enable registration and appointment scheduling prior. 557 patients were vaccinated. The next clinic on Feb 27th intends to vaccinate 750. The one after that will hopefully vaccinate 1500.
7500 citizens vaccinated over 6 clinics
Zero wait times
Patients scheduled and pre-registered (no lines)
NPS score of 90+ (1330+ responses)
This study will use a randomized, controlled superiority trial to evaluate a hospital-wide initiative to improve counseling for postpartum women who experienced hypertension during their pregnancy or in the immediate postpartum period.
Ongoing Research & Analysis
As the University began to scale up the return of students to campus, there was an urgent need to provide COVID-19 testing capabilities as well as the need to communicate the test results back to students. The plan was to leverage the Automated Results Reporting program already developed at the health system and modify it to suit the University's needs. The key differences being a different LIMS system, integration to the red pass management system and escalations sent to Student Wellness and other student specific programs.
38,000+ results communicated
Minimal to no lag in results communication
Minimal increase in staffing
The intent of this study is to help increase the number of serious illness conversations (SICs) and also improve their quality. The program intends to use Fitbits to track physical activity and gather PRO data from cancer patients. The data will be used to create patient specific dashboards that clinicians will use to address the study goals.
Ongoing Research & Analysis
COVID Watch is a successful program that monitors COVID suspected patients at home via self-reported twice daily checkins, primarily focused on dyspnea. COVID Pulse was a program that was developed in parallel that sought to quantify dyspnea levels through the use of a pulse oximeter. The intent of this study was to randomize patients between the two programs to establish the additional value, if any, of the use of pulse oximeters. Enrollment in the program was completed in record time and results are pending publication.
Ongoing Research & Analysis
This project leveraged the success and design on the COVID Watch project and modified it to address the specific needs of the University and it's faculty and students. Once test results were being communicated or symptoms were being, the next step was to be able to monitor students and faculty remotely and address any needs they might have. This project modified COVID Watch to check in with patients once a day (as opposed to twice in Watch) and escalations were directed to student wellness services for mental, physical, food and other related issues. The volume of students enrolled remained low given their demographics and other precautions being taken on campus.
1200+ patients managed
Minimal increase in staffing
Low infection rate
Rollout of Heart Safe Motherhood program to Einstein Health as part of a Philadelphia-wide rollout of the program. This is funded by a grant from Merck via the Safer Cities program. Additional deployments at other Philadelphia based hospitals is ongoing.
Increased guideline adherence by 80%
Reduced 7 day readmission by 80%
Rollout of Heart Safe Motherhood program to Jefferson Health as part of a Philadelphia-wide rollout of the program. This is funded by a grant from Merck via the Safer Cities program. Additional deployments at other Philadelphia based hospitals is ongoing.
Increased guideline adherence by 80%
Reduced 7 day readmission by 80%
Given that testing availability will likely continue to be constrained, symptom tracking based testing could lead to earlier case identification. At the same time, sentinel surveillance will be a critical tool for identifying pre-symptomatic, asymptomatic or mildly symptomatic spread that may evade symptom-based surveillance. Together, this approach provides ability to rapidly identify new cases and conduct contact tracing. This is an RCT that aims to (1) Evaluate the feasibility of a saliva-based screening COVID viral testing program (2) Compare behavioral strategies to improve study enrollment (3)Understand the relationship between daily symptom tracking and identifying infection,
4600+ recruited
65,000+ tests
COVID tests are conducted in advance of procedures or as part of occupational health. These results needed to be communicated to patients in a timely manner. While they were also communicated via the patient portal, immediacy is critical and not all patients have the app installed and activated. Phone calls from a nursing team were expensive and time consuming. An automated system to communicate negative test results (the majority) was put into place to optimize resources while ensuring patient communication.
2100+ results communicated
Increased installs of patient app
COVID Pulse was designed partly in response to reports that some patients with Covid-19 have little dyspnea, despite concerning hypoxemia (low blood oxygen). This program enrolls patients from emergency departments with depressed oxygen saturations, providing them with pulse oximeters, and escalates to care based on declines in measured oxygen saturation.
Enhanced monitoring of patients
Objective escalations based on PulseOx readings
$2.5M PCORI award
The estimated 84 million US adults with prediabetes can significantly reduce their risk of developing type 2 diabetes mellitus (T2DM) by engaging in a Diabetes Prevention Program (DPP) or using metformin. Although these evidence-based clinical preventive services are widely available, very few patients with prediabetes are currently using them. There is thus a critical need to identify ways to increase engagement of patients with prediabetes in strategies to prevent or delay their progression to T2DM. The intent is to try various techniques such as financial incentives (lotteries), self-determination theory (SDT) and tailored messaging to see what works best versus control.
Ongoing Research & Analysis
A Penn Medicine program that automatically checks in with patients at risk for complications of COVID-19 who are self-isolating at home. Patients are monitored 24x7 via text message and escalations managed by a nursing team with full EHR Integration.
20,000+ patients managed
Reduced mortality by 68%
$2.3 Million savings over 100 days
Patient NPS score of 80
Call backs within 30 mins
A variant of the COVID Watch program that automatically checks in specifically with pregnant women at risk for complications of COVID-19 who are self-isolating at home. Patients are monitored 24x7 via text message and escalations managed by an hospital specific nursing teams with full EHR Integration.
80+% patient engagement
Patient NPS score of 76
Covered 208 patients over six months
Vaccinations are critical to getting the country back on track. This program was designed to reach out to patients who either did not have a patient portal account or have a valid email address on file. The intent here was to try and reach out to patients that Penn Medicine interacted with sometime during the last three years and offer the vaccine based on their availability. The program also asked if they already had received the vaccine or were hesitant. The program reached over 300,000 patients and for the people for whom we had accurate information and indicated interest, the conversion rate was around 60%.
300,000+ enrolled
12,000+ appointments scheduled
Test the effectiveness of text-based recruitment strategies to increase participation across four R01 funded research trials targeting hard to reach populations such as smokers and people living with HIV.
Ongoing Research & Analysis
Hypertension monitoring text messaging program for Penn Medicine employees.
Decrease in high blood pressure for participants.
Remote population health management of patients, including medication management.
Women's health intervention after child birth to assist with new mothers with questions and provide support for breastfeeding.
Increase in breastfeeding due to support from text intervention.
Increase in provider and patient communication regarding newborn questions.
Text intervention prompting and monitoring participants to share their social media posts and information with their therapists during their scheduled appointments.
Increased discussion of social media presence in therapy sessions.
Monitoring signs of anxiety and depression in a participant's social media data.
Weekly text message blood pressure monitoring for pregnant women without complications in order to replace office visits with at home monitoring.
Minimize the amount of in-person visits during pregnancy for healthy women.
Monitor patient blood pressures from home and intervene as necessary.
To evaluate the effectiveness of behavioral economic approaches to increase patient mobility and reduce mobility disability and postoperative complications.
Ongoing Research & Analysis
Test an escalating lottery-based incentive tied to daily self-weighing for weight loss maintenance
Mean weight changes at the end of phase 1 were −1.1 kg in the incentive group and −1.9 kg in the control group
At the end of phase 2, mean weight changes were 0.2 kg in the incentive group and −0.6 kg in the control group
Implement a novel intervention using mobile technology and social incentives to increase physical activity for women with preeclampsia or gestational hypertension.
Ongoing Research & Analysis
Looking at improving mobility in the inpatient setting specifically through goal setting and gamification.
Ongoing Research & Analysis
The broad objective of this study is to develop and test a digital health intervention using a behavioral economics framework to increase the amount of time people spend in nature.
Ongoing Research & Analysis
Use social incentives and gamification to increase physical activity among overweight and obese adults.
Gamification interventions had significant increase in activity
Competitive intervention had more sustained activity (post study)
Developed a text message navigation program to improve colonoscopy show rates, reduce cancellations and improve quality / adherence to procedure prep.
Improved show rate by 30%
Maintained or improved quality of prep
Randomized crossover trial of different types of intra-articular injections and financial incentives will also be used to promote adherence to the completion of the patient-reported outcomes.
Ongoing Research & Analysis
Test the effectiveness of remote monitoring, automated reminders, performance feedback and incentives among children with asthma.
Ongoing Research & Analysis
Evaluate the impact of monitoring adherence with electronic pill bottles or bidirectional text messaging on improving hypertension control.
Mean change values in systolic blood pressure were − 4.7 (23.4) mmHg in usual care, − 4.3 (21.5) mmHg in the pill bottle arm, and − 4.6 (19.8) mmHg in the text arm
No significant change in systolic blood pressure between control and the pill bottle arm
The overall goal of this study is to test if behavioral economic approaches will reduce apathy, and subsequently, improve goal-directed behavior in Parkinson’s disease.
Ongoing Research & Analysis
These modules allow patients to text message photos via Penn Medicine’s Way to Health (W2H) platform directly into the EPIC electronic medical record. Currently, patients are offered the choice to submit their photos through myPennMedicine, our patient portal, or text message prior to teledermatology appointments. Patients receive text messages upon scheduling that instruct them to submit their photos. If they choose the text message option, they receive step-by-step guidance (with links to example images).
Ongoing Research & Analysis
Text conversations to monitor drain outputs of patients who’ve received breast reconstructive surgery. These tailored conversations comply with 20 cc and 30 cc drain management. Texts ask patients their daily output to determine if they are at criteria and need a drained pulled from a home health nurse until they have no drains left.
Post-op visits reduced from 5 to 1
Per patient time savings of 15 hours
Significant contribution margin
New Home Health revenue
Text conversations to monitor patients’ ostomy output levels after an ileostomy procedure. Patients can send in output values throughout the day, whenever they empty their ostomy bag. We calculate their levels over varying hours to determine total output and compare against thresholds. If these reported outputs are above or below thresholds, patient’s care team is alerted to engage in high-touch care that could lead to a home infusion visit. This surfaces patients who are at risk of post-op readmission.
Reduced post-op visits
Reduced hospital readmissions by 54%
Increased patient satisfaction
Assessed whether the interventions, based on principles from behavioral economics, might improve statin adherence and lipid control in at-risk populations.
Achieved enrollment targets
Health system enrollment was cost-efficient
Design a scalable model for capturing patient level data to develop, implement, and evaluate EMR defaults to “right-size” opioid prescribing for acute painful episodes and routine surgical procedures.
Ongoing Research & Analysis
Test the effectiveness of remote monitoring of glucose plus lottery financial incentives among low-income patients suffering from diabetes.
Ongoing Research & Analysis
This pilot will answer questions important to the feasibility of conducting a well-powered randomized controlled trial to improve adherence among African American HIV patients within the US who have suboptimal adherence using CVS and Aetna claims data to identify such patients, CVS/Aetna communications channels to enroll them, and incentives to achieve high levels of ongoing participation.
Ongoing Research & Analysis
Testing how financial incentives and gamification can improve moderate-to-vigorous physical activity.
Ongoing Research & Analysis
Pilot grant to test feasibility of incentivizing various behaviors and outcomes associated with gestational weight gain.
Ongoing Research & Analysis
Testing a 2x2x2x2x2 factorial design to optimize components for a sleep extension intervention for children.
Ongoing Research & Analysis
Implementation of this novel ERAS pathway for patients undergoing elective spine or peripheral nerve surgery safely reduces patients’ postoperative opioid requirements during hospitalization and 1 month postoperatively. ERAS results in improved postoperative mobilization and ambulation.
Post-op intravenous opioid meds nearly eliminated
3x greater mobility on post-op day 0
Test the effectiveness of a mobile app to replace in person therapy sessions and to track physical health through an activity tracker among depressed adults older than 50 years.
Test the effectiveness of a mindfulness app among youth 13-22 years old. This will be a three arm trial leveraging gamification and supportive social incentives approaches.
A simple observational study with a very small group of VA patients with Parkinsons (30 odd). Patients will register their fitbits and collect movement and MVPA data over 2 weeks. Intent is to figure out if this patient population would actually use it and if the data provides any insight.
Ongoing Research & Analysis
Blood pressure monitoring for pregnant women with a diagnosis of pre-eclampsia. They will be recruited via EPIC. The project/study leverages bidirectional messaging for BP monitoring and escalation to provider / care team on an exception basis. Rollout to Penn Hospitals is not complete.
Increased guideline adherence by 80%
Reduced 7 day readmission by 80%
Investigate how social supports, automated alerts, and their combination improve medication adherence.
52.9% adherence in alert arm
54.5% adherence in partner + alert arm
36.0% adherence in control arm
Evaluate the use of a mobile application (app) in patients already using total body photography (TBP) to increase skin self-examination (SSE) rates and pilot the effectiveness of examination reminders and accountability partners.
SSE rates increased from 58% to 83% at 6 months in intervention groups
Randomized crossover trial of different types of intra-articular injections in osteoarthritic patients. Monitor physical activity and patient-reported outcomes over 3 months after each injection. Financial incentives will also be used to promote adherence to the completion of the patient-reported outcomes.
Test the effectiveness of a pledge system and nudge messaging to purchase naloxone within one week of training. Population is staff and patrons of Free Library of Phila.
Ongoing Research & Analysis
SMS Conversations intervention, assessing participants use of medication, pain and other symptoms via survey. 3 arms have been designed - control, intervention and intervention plus incentive. Deployed at the VA for opioid patients.
Ongoing Research & Analysis
Assessing long-term recovery and potential for connection with trauma patients after injury through Survey administration, bi-directional texts, and sleep tracking (Fitbits). We propose to conduct pilot research for a remote monitoring intervention to improve long- term injury recovery.
Ongoing Research & Analysis
A multi-site, RCT that will evaluate the effectiveness of trained pre-med post-baccalaureate health coaches in chronic disease management. Our primary outcomes are changes in weight, physical activity, dietary choices, and patient engagement throughout the 16-week intervention. In our proof of concept (n=22), participants increased their physical activity by an average of 60 minutes per week, responded to 70% of messages, and lost 4.6% their bodyweight over 16 weeks.
Financial incentives, pharmacologic therapies, and electronic cigarettes (e-cigarettes) to promote smoking cessation
Large scale pragmatic trial using opt-out for enrollment
Redeemable deposits and rewards were superior to free cessation aids
Improve cardiac outcomes after heart attacks and cardiac stent placements through the use of financial incentives and a wearable sleep and step tracking device
Incentive arm had an increase of 1388 mean daily steps from baseline
Control arm had an increase of 385 mean daily steps from baseline
The purpose of this study is to determine how goal-setting in the context of gamification affects habit formation for physical activity among participants who are overweight or obese. We plan to use the gamification features of the Way to Health platform and the step tracking feature of to test the impact of two separate goal-setting features including 1. actively choosing a step goal versus being assigned a step goal and 2. being asked to immediately meet that goal versus being asked to make incremental changes towards that goal over an 8 week period.
Ongoing Research & Analysis
As part of this project, we will be using the Way to Health platform to send/receive text messages to adolescents and will be using financial incentives.
Ongoing Research & Analysis
Gain a deeper understanding of teen perspectives on how to overcome the barriers to the use of cellphone blocking technology and facilitate improved research and implementation strategies.
Teens willing to give up reading texts (90%), sending texts (95%), social media (99%) while driving
Not willing to give up navigation (59%) and music applications (43%)
Rollout of Heart Safe Motherhood program at Northwestern University and the University of North Carolina.
Ongoing Research & Analysis
Compares different methods of data collection from wearable devices to develop enhanced risk prediction models for changes in glycemic control among pre-diabetic adults.
Ongoing Research & Analysis
Test effectiveness of social incentive-based gamification intervention to increase physical activity among overweight and obese veterans. VA funding Withings device BMI stratification participation incentives only potentially 4 week ramp Arms: 1. Control- just device (60) 2. Supportive social incentive (60) 3. Supportive social incentive + $ (60)
Ongoing Research & Analysis
Examine the effect of an opt-out default recruitment strategy compared to a conventional opt-in strategy on enrollment and adherence to a behavioral intervention for poorly controlled diabetic patients
Enrollment rates were 38% in the opt-out arm and 13% in the opt-in arm
496 were randomized to the opt-in arm and 73 to the opt-out arm
Randomized crossover trial of different types of intra-articular injections (population: osteoarthritis at the VA). W2H to be used to monitor physical activity (activity monitors) and patient-reported outcomes over the 3 months after each injection. Financial incentives will also be used to promote adherence to the completion of the patient-reported outcomes.
Ongoing Research & Analysis
Adolescents will be randomized to 1 of 3 financial incentive groups: (1) reward-based, with each adolescent receiving incremental $15-45 payments submitted into a virtual account when program benchmarks for the Quitline are achieved (maximum $150); (2) loss-framed, with $150 deposited into a virtual account, with $15-45 losses deducted from the account for each benchmark not achieved, with withdrawal only allowed at the end of the study; and (3) no financial incentive. The Quitline is funded by the Pennsylvania Department of Health and staffed by trained cessation counselors available 24 hours a day, 7 days a week.
Ongoing Research & Analysis
Use Way to Health to track and promote longer sleeping habits among adolescents. Interested in using social normatives on top of loss framed incentives. 4 arms- control, normative feedback (team), loss framed incentive, loss + normative $50 incentive text messages and sleep hygiene tips
Ongoing Research & Analysis
Use Way to Health to track step counts, heart rate and intensity in patients with cardiovascular disease. Wants to build this remote monitoring into clinical practice. Fitbit Charge 2- low, moderate, vigorous activity Goals and targets Text feedback
Ongoing Research & Analysis
Collecting and studying the impact of patient reported outcomes on satisfaction and survivorship. Targeted at patients with advanced non-small cell lung cancer initiating chemotherapy, includes symptom assessment and provider alerts
Ongoing Research & Analysis
Studying the impact of activity on breast cancer patients. Incentives and gamification techniques are also being tested.
Ongoing Research & Analysis
In BBT, COPD patients receive daily breathing check-ins by text message and escalations are sent to their care team through cureatr, email, and EPIC inbasket. The existing program will be rebuilt so that patients will automatically flow from 45 days of daily monitoring with escalations sent to their inpatient team to indefinite weekday monitoring with escalations sent to the nurse pool associated with their pulmonologist. There will also be a workflow for high risk patients to receive indefinite daily monitoring. A rebuild is underway to enhance the program. The rebuild will include non-adherence tracking, automated handling of readmissions, discharges, and deaths, and simplified daily check-in text language.
Reduced readmissions by 44%
Cost savings of over $7000 per re-admission
Increased patient satisfaction
Effectiveness of daily financial incentives on glucose monitoring adherence and glycemic control in adolescents & young adults with type 1 diabetes.
Effectiveness of financial incentives
Improved glucose monitoring by 62%
Gamification designed to leverage insights from behavioral economics offers a promising approach to improve daily health behaviors at low cost
Increased activity achievement by 50%
Post study activity increased by 27%
Reduce 30-day readmissions for cirrhosis and post-transplant patients by remotely monitoring weight, mental function, medication adherence and temperature
Reduced 7-day readmissions by 43%
Reduced preventable readmits by 75%
Complex study focused on reducing occurrence of kidney stones via hydration. Study includes devices, incentives, choose your own path and multiple other models.
Ongoing Research & Analysis
Larger trial building on Livebetter Phase 1. Focused on automated hovering of cirrhosis and liver transplant patients
Ongoing Research & Analysis
Intent of the trial is to assist depressed adults with primary care treatment. W2H is used to automate the trial with respect to randomization, measurement of medication adherence via electronic pill bottle, and distribution of financial incentives to patients.
Ongoing Research & Analysis
Determine whether a system of medication reminders using financial incentives and social support delays subsequent vascular events in patients.
No significant increase in medication adherence
Did not reduce the rate of vascular readmission
Ongoing Research & Analysis
Text messages sent to patients post-surgery to help with recovery. These text messages are sent over the course of 7-10 days depending on the type of procedure. The text content is tailored to reminding patients on how to clean wounds, drink fluids to stay hydrated, and inform them of any dietary restrictions in place after surgery.
Patient compliance increased to 90+%
Readmission reduction of 50-85%
Length of stay reduction of 20-30%
Test effectiveness of reminders and recovery tips in reducing readmissions following Gynecologic Oncology surgery.
Ongoing Research & Analysis
Use W2H to track mobility and examine how it relates to nurse mobility assessment scores; W2H would be used to passively collect data via wearable. Partnered with Scott Halpern for testing $ in enrollment - now looking at cancer patients as well- recruiting from Cancer floors - enrollment incentives Control- mobility assessment Intervention- told mobility score and mobility assessment 1 daily feedback message Target for intervention arm participants: Participants in the intervention arm will have a weekly step goal that increases from baseline by 10% each week of the intervention (12 weeks) with a maximum of 10,000 steps
Ongoing Research & Analysis
The purpose of this study is to assess the acceptability of the W2H patient portal in patients seeking AD treatment. The W2H portal will include data from the following: PH indices from the Withings health monitor and nursing assessments, responses to electronic momentary assessment (eMA) text messaging prompts, self-report and clinician-interview AD symptom ratings, and cognitive/psychophysiological assessments.
Ongoing Research & Analysis
The proposed pilot program will develop a bidirectional W2H SMS medication adherence platform to tailor patient specific medication reminders and medication assistance inquiries. 50 patients with a diagnosis of depression and anxiety prescribed ≥1 medication for that disorder (i.e. the intervention group) will be enrolled. Using propensity score matching, study patients will be matched.
Ongoing Research & Analysis
Leverage the W2H platform to develop and evaluate a new hypertension service-delivery model that is integrated with routine clinical care at Penn Family Care (PFC), an academic family medicine practice in West Philadelphia. Among patients with poorly controlled HTN, we will assess the effects of monitoring blood pressure and medication adherence with feedback to the patient and to the clinical practice, as needed if out of control. We will also compare the impact of providing feedback to a social support partner with what we call facilitated cheer leading.
Ongoing Research & Analysis
The effects of financial incentives, donations to charity, and the combined effects of both interventions on older adults’ uptake and retention of increased levels of walking
Proportion of days step goals were met was higher in intervention groups versus controls
Incentive schemes increase older adults’ initial uptake of increased levels of walking
Impact of a pill bottle used to monitor adherence, delivery a daily alarm, and generate weekly medication adherence feedback reports on statin adherence.
89% of Individual feedback group adhered to taking their statin medication
86% of partner feedback group adhered to taking their statin medication
Wireless-enabled pill bottles with adherence data to providers to improve adherence and help providers identify adherence barriers
Mean adherence was 88% in the reminders + notifications arm
Mean adherence was 78% in the reminders arm
Mean adherence was 55% in the control arm
Reduce 7-day readmissions for hypertension among postpartum women and creating a national leadership model to meet ACOG guidelines
Increased guideline adherence by 80%
Reduced 7 day readmission by 80%
Test different methods of collecting patient-generated health data including self-reported Survey administration, smartphones, and a wearable activity tracking device. The overall objective of the study is to develop algorithms for the dynamic and timely prediction of health care utilization using a multimodal, integrated dataset from insurer and pharmacy claims, electronic health records, and patient-generated health data.
novel method of remotely-monitoring patient behaviors after hospital discharge
nform new ways to improve the identification of patients at high-risk for hospital readmission
Test effectiveness of reminders and recovery tips in reducing readmissions following Orthopaedic surgery.
Ongoing Research & Analysis
Compare the efficacy of a lottery-based incentive, traditional direct payment incentive, and control of daily feedback without any incentive for weight-loss maintenance.
12% of candidates created an account on the study website
Yielded 191 randomized participants
Compare the efficacy of two 6-month mhealth-based interventions to promote treatment adherence among young adults post kidney transplant or spinal bifida.
Ongoing Research & Analysis
Test effectiveness of weekly check ins and appt reminders in reducing over utilization of healthcare services
Ongoing Research & Analysis
Compare the effectiveness of different combinations of social comparison feedback and financial incentives to increase physical activity.
Incentive group mean proportion achieving the 7000-step goal was 0.45
Control group mean proportion achieving the 7000-step goal was 0.27
Test whether employer matching of employees’ monetary contributions increases employees’ participation in deposit contracts to promote weight loss and weight loss.
At 24 weeks, control participants gained an average of 1 lb and 1:1 match participants lost an average of 5.3 lbs
Matching deposits did not increase participation
The objective of this study is to use a randomized, controlled trial to test the effectiveness of three interventions using social incentives and gamification to promote physical activity, weight loss, and improved glycemic control among adult type 2 diabetics.
Gamification interventions had significant increase in activity
No significant changes in weight or A1c levels
Compare the effectiveness of individual versus team-based financial incentives to increase physical activity.
Combined incentive arm achieved goal at greater rates than the team incentive (0.35 vs. 0.17)
Combined incentive had greater mean daily steps than control (difference: 1446)
Participants receive a smartphone breathalyzer to provide feedback on their estimated blood alcohol level. The intervention compares loss- and gain-framed messages that make the consequences of drinking and driving more salient to standard messages not to drink and drive.
Ongoing Research & Analysis
Use W2H to develop a protocol to efficiently recruit and enroll pediatric and adult concussion patients from the ED, and monitor and integrate their data in real time daily. The primary outcome is the mean proportion of participant days that the 2000-step goal was achieved for each group for each day of the study.
Ongoing Research & Analysis
Intent of the study is to increase physical activity to decrease post-operative morbidity for radical cystectomy patients
Ongoing Research & Analysis
The primary goal of this pilot study will be to determine whether one incentive (loss aversion) is better than no incentive in increasing step counts and maintaining an increased level of physical activity among RA patients. The primary outcome will be percent of days meeting goal during the intervention period.
Ongoing Research & Analysis
Improve adherence through real-time feedback based on theories of how social forces influence behavior
High pill-bottle adherence (90% in PROMOTE, 92% in SUPPORT)
Participants had low baseline MPRs (median = 60%, IQR 41–72%)
Test the effectiveness of 3 methods to frame financial incentives to increase physical activity among overweight and obese adults.
In control, mean proportion achieving the goal was 0.30
In gain-incentive group, mean proportion achieving the goal was 0.35
In lottery-incentive group, mean proportion achieving the goal was 0.36
In loss-incentive group, mean proportion achieving the goal was 0.45
Test effectiveness of reminders and recovery tips in reducing readmissions following colorectal surgery.
Ongoing Research & Analysis
Premium-based financial incentives to promote workplace weight loss
Control group had a mean gain of 0.1 pounds
Delayed-premium adjustment group had a mean loss of 1.2 pounds
Immediate-premium adjustment group had a mean loss of 1.4 pounds
Daily lottery incentive group had a mean loss of 1.0 pounds
Shared physician and patient incentives are more effective in reducing levels of low-density lipoprotein cholesterol (LDL-C) among patients with high CVD risk.
Reduced LDL-C by 33%
Aligned patient and provider incentives
Improve adherence and functional outcomes of adults adults with Obstructive Sleep Apnea (OSA) using daily Web-based access to their positive airway pressure (PAP) with or without a financial incentive.
Average daily PAP use was 4.7 ± 3.3 h in the usual care group
Average daily PAP use was 5.9 ± 2.5 h and 6.3 ± 2.5 h in the Web access groups
Financial incentives to quit smoking work and even more so when own money is staked. Program rolled out across all CVS employees.
Rewards quit rate - 17.1%
Personal stake quit rate - 52.3%
Test effectiveness of automated hovering of scale and medication adherence with daily lotteries to improve outcomes for UPHS CHF patients. The goal of the proposed project is to conduct a pragmatic randomized controlled trial testing a new approach to chronic disease management combining wireless monitoring devices and behavioral economic engagement incentives to reduce rehospitalization rates among patients with Congestive Heart Failure (CHF) recently hospitalized at the University of Pennsylvania Health System (UPHS).
Ongoing Research & Analysis
Test effectiveness of two different magnitudes of financial incentives for improving adherence to remote-monitoring regimens among patients with diabetes.
Low incentive arm had an adherence rate of 62%
High incentive arm had an adherence rate of 35%
Control arm had adherence rate of 27%
Test Effectiveness of two financial incentive designs for promoting weight loss among obese employees
Group incentive participants lost 9.7 lbs more than other participants
At 12 weeks, group arm participants maintained greater weight loss
Test effectiveness of improving cholesterol levels among participants who are at high risk of CVD and who have elevated LDL cholesterol levels by testing process versus outcomes financial incentives. The primary outcome will be change in LDL cholesterol over 12 months. Last day of intervention is 4/14/2018. End of follow up period is 10/11/2018.
Ongoing Research & Analysis
Determine whether peer mentors or financial incentives are superior to usual care in helping African American Veterans improve their HbA1c levels.
Peer mentorship improved glucose control
Financial incentives did not significantly decrease glucose control